01903nas a2200253   4500008004100000245007800041210006900119260000800188520096500196100002401161700001601185700002101201700001901222700002201241700002001263700002301283700002001306700001901326700002001345700001801365700002001383700001501403856023101418       2002                        eng d00aUnited {States} {Patent}: 6454945 - {Microfabricated} devices and methods0 aUnited States Patent 6454945 Microfabricated devices and methods  csep3 aThis invention provides microfabricated systems for extraction of desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers. Such diffusion-based mixing or sensing devices are preferably channel cell systems for detecting the presence and/or measuring the quantity of analyte particles in a sample stream.1 aWeigl, Bernhard, H.1 aYager, Paul1 aBrody, James, P.1 aHoll, Mark, R.1 aForster, Fred, K.1 aAltendorf, Eric1 aGalambos, Paul, C.1 aKenny, Margaret1 aSchutte, David1 aHixson, Gregory1 aZebert, Diane1 aKamholz, Andrew1 aWu, Caicai  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=25&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2201074nas a2200145   4500008004100000245010600041210006900147260000800216520038500224100002200609700002300631700002400654700001900678856023100697       2000                        eng d00aUnited {States} {Patent}: 6134950 - {Method} for determining concentration of a laminar sample stream0 aUnited States Patent 6134950 Method for determining concentratio  coct3 aA method and apparatus including programmed computers are provided for determining the viscosity of a first stream in a laminar flow and a second stream in a laminar flow, the flow rates, the centerline of the flow channel, and the position of the interface between the streams with respect to the centerline, and for calculating viscosity ratio of the first stream to the second.1 aForster, Fred, K.1 aGalambos, Paul, C.1 aWeigl, Bernhard, H.1 aHoll, Mark, R.  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=33&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%2201104nas a2200133   4500008004100000245010600041210006900147520043500216100002200651700002300673700002400696700001900720856023100739       1999                        eng d00aUnited {States} {Patent}: 5974867 - {Method} for determining concentration of a laminar sample stream0 aUnited States Patent 5974867 Method for determining concentratio3 aMethods and apparatuses including programmed computers are provided for determining the initial concentration of diffusible particles in a sample stream introduced into a system wherein the sample stream which contains the diffusible particles flows in adjacent laminar flow with an indicator stream containing an indicator substance capable of exhibiting an observable change at a known concentration of the diffusible particles.1 aForster, Fred, K.1 aGalambos, Paul, C.1 aWeigl, Bernhard, H.1 aHoll, Mark, R.  uhttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=35&f=G&l=50&co1=AND&d=PTXT&s1=%22Weigl%3B+Bernhard%22.INNM.&OS=IN/%22Weigl;+Bernhard%22&RS=IN/%22Weigl;+Bernhard%22