@article {23,
	title = {PEG-PE/phosphatidylcholine mixed immunomicelles specifically deliver encapsulated taxol to tumor cells of different origin and promote their efficient killing.},
	journal = {J Drug Target},
	volume = {11},
	year = {2003},
	month = {2003 Feb},
	pages = {87-92},
	abstract = {<p>Mixed micelles were prepared from poly(ethyleneglycol)-distearyl phosphoethanolamine (PEG2000-PE) and egg phosphatidylcholine. The micelles were covalently modified with the nucleosome-specific monoclonal antibody 2C5 known to recognize and bind a variety of tumor cells via their surface-bound nucleosomes. Covalent attachment of 2C5 antibody was performed via a micelle-incorporated PEG-PE with the distal terminus of the PEG block activated with p-nitrophenylcarbonyl group (pNP-PEG-PE). Micelle surface-attached 2C5 antibody maintained its specific activity. 2C5-targeted immunomicelles were able to carry more than 3 wt\% of taxol. Taxol-loaded immunomicelles specifically recognized tumor cell lines of several types. The cytotoxicity of 2C5-targeted taxol-loaded immunomicelles in a cell culture model was much higher when compared with free taxol or taxol in non-targeted micelles.</p>},
	keywords = {Animals, Antibodies, Monoclonal, Antineoplastic Agents, Cell Survival, Chromatography, High Pressure Liquid, Drug Carriers, Electrophoresis, Polyacrylamide Gel, Mice, Micelles, Nucleosomes, Paclitaxel, Particle Size, Phosphatidylcholines, Phosphatidylethanolamines, Polyethylene Glycols, Tumor Cells, Cultured},
	issn = {1061-186X},
	doi = {10.1080/1061186031000138623},
	author = {Gao, Z and Lukyanov, A N and Chakilam, A R and Torchilin, V P}
}
