@article {21,
	title = {Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits.},
	journal = {J Control Release},
	volume = {94},
	year = {2004},
	month = {2004 Jan 8},
	pages = {187-93},
	abstract = {<p>Micelles prepared from polyethyleneglycol/phosphatidyl-ethanolamine conjugates (PEG-PE) with a size of 7-20 nm and zeta-potential of approximately -18 mV were administered i.v. to rabbits with experimental myocardial infarctions. Micelles demonstrated a prolonged circulation in the blood (half-life of 2 h) and accumulated in the infarction zone with efficiency more than 8-fold higher as compared to a non-damaged part of the heart muscle. Obtained results suggest that the enhanced permeability and retention (EPR) effect is the primary mechanism of accumulation of microparticles in the infarct areas, and that drug carriers such as PEG-PE micelles can be used for the delivery of therapeutic or diagnostic agents to an area of myocardial infarction.</p>},
	keywords = {Animals, Arterial Occlusive Diseases, Disease Models, Animal, Electrocardiography, Male, Micelles, Myocardial Infarction, Phosphatidylethanolamines, Polyethylene Glycols, Rabbits},
	issn = {0168-3659},
	author = {Lukyanov, Anatoly N and Hartner, William C and Torchilin, Vladimir P}
}
@article {17,
	title = {PEGylated dextran as long-circulating pharmaceutical carrier.},
	journal = {J Biomater Sci Polym Ed},
	volume = {15},
	year = {2004},
	month = {2004},
	pages = {621-30},
	abstract = {<p>Dextran-polyethylene glycol (PEG) conjugates were synthesized by activating dextran hydroxy groups with carbonyldiimidazole, introducing amino groups by attaching ethylenediamine, and reacting amino groups with a succinimidyl-activated derivative of PEG. Conjugates with an average of 12 and 21 PEG (5 kDa) residues per single dextran (73 kDa) molecule were prepared. These conjugates have circulation half-lives of 5.3 h and 7.0 h, respectively, compared to 4.0 h for non-PEGylated dextran. The modification of dextran with PEG inhibits the uptake of polymer by the major organ of the reticuloendothelial system, the liver. Dextran-PEG conjugates may represent a convenient platform for long-circulating pharmaceutical preparations.</p>},
	keywords = {Animals, Dextrans, Drug Carriers, Female, Half-Life, Mice, Mice, Inbred C57BL, Polyethylene Glycols, Polymers, Tissue Distribution},
	issn = {0920-5063},
	author = {Lukyanov, Anatoly N and Sawant, Rishikesh M and Hartner, William C and Torchilin, Vladimir P}
}
