@article {17,
	title = {PEGylated dextran as long-circulating pharmaceutical carrier.},
	journal = {J Biomater Sci Polym Ed},
	volume = {15},
	year = {2004},
	month = {2004},
	pages = {621-30},
	abstract = {<p>Dextran-polyethylene glycol (PEG) conjugates were synthesized by activating dextran hydroxy groups with carbonyldiimidazole, introducing amino groups by attaching ethylenediamine, and reacting amino groups with a succinimidyl-activated derivative of PEG. Conjugates with an average of 12 and 21 PEG (5 kDa) residues per single dextran (73 kDa) molecule were prepared. These conjugates have circulation half-lives of 5.3 h and 7.0 h, respectively, compared to 4.0 h for non-PEGylated dextran. The modification of dextran with PEG inhibits the uptake of polymer by the major organ of the reticuloendothelial system, the liver. Dextran-PEG conjugates may represent a convenient platform for long-circulating pharmaceutical preparations.</p>},
	keywords = {Animals, Dextrans, Drug Carriers, Female, Half-Life, Mice, Mice, Inbred C57BL, Polyethylene Glycols, Polymers, Tissue Distribution},
	issn = {0920-5063},
	author = {Lukyanov, Anatoly N and Sawant, Rishikesh M and Hartner, William C and Torchilin, Vladimir P}
}
